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COMMUNICATIONS
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3193-3198
| Discovery of Novel Disaccharide Antibacterial Agents Using a Combinatorial Library Approach
Michael J. Sofia,
Nigel Allanson,
Nicole T. Hatzenbuhler,
Rakesh Jain,
Ramesh Kakarla,
Natan Kogan,
Rui Liang,
Dashan Liu,
Domingos J. Silva,
Huiming Wang,
David Gange,
Jan Anderson,
Anna Chen,
Feng Chi,
Richard Dulina,
Buwen Huang,
Muthoni Kamau,
Chunguang Wang,
Eugene Baizman,
Arthur Branstrom,
Neil Bristol,
Robert Goldman,
Kiho Han,
Clifford Longley,
Sunita Midha, and
Helena R. Axelrod
[Full Article -
PDF]
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3199-3202
| PTP1B Inhibition and Antihyperglycemic Activity in the ob/ob Mouse Model of Novel 11-Arylbenzo[b]naphtho[2,3-d]furans and 11-Arylbenzo[b]naphtho[2,3-d]thiophenes
Jay Wrobel,
Janet Sredy,
Christopher Moxham,
Arlene Dietrich,
Zenan Li,
Diane R. Sawicki,
Laura Seestaller,
Li Wu,
Alan Katz,
Donald Sullivan,
Cesario Tio, and
Zhong-Yin Zhang
[Full Article -
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EXPEDITED ARTICLES
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3203-3209
| Structure-Based Identification of Small Molecule Antiviral Compounds Targeted to the gp41 Core Structure of the Human Immunodeficiency Virus Type 1
Asim Kumar Debnath,
Lin Radigan, and
Shibo Jiang
[Full Article -
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ARTICLES
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3210-3216
| Lead Generation Using Pharmacophore Mapping and Three-Dimensional Database Searching: Application to Muscarinic M3 Receptor Antagonists
David P. Marriott,
Iain G. Dougall,
Premji Meghani,
Yu-Jiang Liu, and
Darren R. Flower
[Full Article -
PDF]
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3217-3226
| Quantitative Structure-Activity Relationship Modeling of Dopamine D1 Antagonists Using Comparative Molecular Field Analysis, Genetic Algorithms-Partial Least-Squares, and K Nearest Neighbor Methods
Brian Hoffman,
Sung Jin Cho,
Weifan Zheng,
Steven Wyrick,
David E. Nichols,
Richard B. Mailman, and
Alexander Tropsha
[Full Article -
PDF]
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3227-3242
| Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine-Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease
Pelayo Camps,
Rachid El Achab,
Diana Marina Görbig,
Jordi Morral,
Diego Muñoz-Torrero,
Albert Badia,
Josep Eladi Baños,
Nuria María Vivas,
Xavier Barril,
Modesto Orozco, and
Francisco Javier Luque
[Full Article -
PDF]
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3243-3250
5'-Phosphoramidates and 5'-Diphosphates of 2'-O-Allyl- -D-arabinofuranosyl- uracil, -cytosine, and -adenine: Inhibition of Ribonucleotide Reductase
Stefano Manfredini,
Pier Giovanni Baraldi,
Elisa Durini,
Silvia Vertuani,
Jan Balzarini,
Erik De Clercq,
Anna Karlsson,
Valentina Buzzoni, and
Lars Thelander
[Full Article -
PDF]
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3251-3264
| New 4-Point Pharmacophore Method for Molecular Similarity and Diversity Applications: Overview of the Method and Applications, Including a Novel Approach to the Design of Combinatorial Libraries Containing Privileged Substructures
Jonathan S. Mason,
Isabelle Morize,
Paul R. Menard,
Daniel L. Cheney,
Christopher Hulme, and
Richard F. Labaudiniere
[Full Article -
PDF]
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3265-3278
| Novel Antidiabetic and Hypolipidemic Agents. 5. Hydroxyl versus Benzyloxy Containing Chroman Derivatives
K. Anji Reddy,
B. B. Lohray,
V. Bhushan,
A. Sekar Reddy,
N. V. S. Rao Mamidi,
P. Papi Reddy,
V. Saibaba,
N. Jaipal Reddy,
A. Suryaprakash,
Parimal Misra,
Reeba K. Vikramadithyan, and
R. Rajagopalan
[Full Article -
PDF]
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3279-3288
| Novel Arylpyrazino[2,3-c][1,2,6]thiadiazine 2,2-Dioxides as Platelet Aggregation Inhibitors. 2. Optimization by Quantitative Structure-Activity Relationships
Nuria Campillo,
Pilar Goya, and
Juan A. Páez
[Full Article -
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3289-3299
| Structural Modification of Fas C-Terminal Tripeptide and Its Effects on the Inhibitory Activity of Fas/FAP-1 Binding
Eiji Sawa,
Motoo Takahashi,
Masaru Kamishohara,
Tetsushi Tazunoki,
Kaname Kimura,
Midori Arai,
Tetsuko Miyazaki,
Shiro Kataoka, and
Tsuyoshi Nishitoba
[Full Article -
PDF]
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3300-3307
| Synthesis and Properties of 3-(2-Hydroxyethyl)-3-n-pentyldiazirine, a Photoactivable General Anesthetic
S. Shaukat Husain,
Stuart A. Forman,
Marek A. Kloczewiak,
George H. Addona,
Richard W. Olsen,
Megan B. Pratt,
Jonathan B. Cohen, and
Keith W. Miller
[Full Article -
PDF]
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3308-3314
| Virtual Combinatorial Syntheses and Computational Screening of New Potential Anti-Herpes Compounds
Jesus V. de Julián-Ortiz,
Jorge Gálvez,
Carlos Muñoz-Collado,
Ramón García-Domenech, and
Concepción Gimeno-Cardona
[Full Article -
PDF]
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3315-3323
Synthesis and Evaluation of 3-Trifluoromethyl-7-substituted- 1,2,3,4-tetrahydroisoquinolines as Selective Inhibitors of Phenylethanolamine N-Methyltransferase versus the  2-Adrenoceptor
Gary L. Grunewald,
Timothy M. Caldwell,
Qifang Li, and
Kevin R. Criscione
[Full Article -
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3324-3333
| Design of Highly Active Analogues of the Pyrrolo[1,2-a]benzimidazole Antitumor Agents
William A. Craigo,
Benjamin W. LeSueur, and
Edward B. Skibo
[Full Article -
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3334-3341
| Thiazolothiazepine Inhibitors of HIV-1 Integrase
Nouri Neamati,
Jim A. Turpin,
Heather E. Winslow,
John L. Christensen,
Karen Williamson,
Ann Orr,
William G. Rice,
Yves Pommier,
Antonio Garofalo,
Antonella Brizzi,
Giuseppe Campiani,
Isabella Fiorini, and
Vito Nacci
[Full Article - PDF]
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3342-3355
| N-Substituted (2,3-Dihydro-1,4-benzodioxin-2-yl)methylamine Derivatives as D2 Antagonists/5-HT1A Partial Agonists with Potential as Atypical Antipsychotic Agents
Alan M. Birch,
Paul A. Bradley,
Julie C. Gill,
Frank Kerrigan, and
Pat L. Needham
[Full Article - PDF]
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3356-3368
| Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase
Neville J. Anthony,
Robert P. Gomez,
Micheal D. Schaber,
Scott D. Mosser,
Kelly A. Hamilton,
Timothy J. O'Neil,
Kenneth S. Koblan,
Samuel L. Graham,
George D. Hartman,
Daksha Shah,
Elaine Rands,
Nancy E. Kohl,
Jackson B. Gibbs, and
Allen I. Oliff
[Full Article - PDF]
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3369-3377
| Probing the Topological Arrangement of the N- and C-Terminal Residues of Bradykinin for Agonist Activity at the B1 Receptor
Maria Pellegrini,
Mariella Tancredi,
Paolo Rovero, and
Dale F. Mierke
[Full Article - PDF]
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3378-3389
| Synthesis of 5-(Carboranylalkylmercapto)-2'-deoxyuridines and 3-(Carboranylalkyl)thymidines and Their Evaluation as Substrates for Human Thymidine Kinases 1 and 2
Anthony J. Lunato,
Jianghai Wang,
Jeffrey E. Woollard,
Abul K. M. Anisuzzaman,
Weihua Ji,
Feng-Guang Rong,
Seiichiro Ikeda,
Albert H. Soloway,
Staffan Eriksson,
David H. Ives,
Thomas E. Blue, and
Werner Tjarks
[Full Article - PDF]
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3390-3399
| Asymmetric Synthesis and Antiviral Activities of L-Carbocyclic 2',3'-Didehydro-2',3'-dideoxy and 2',3'-Dideoxy Nucleosides
Peiyuan Wang,
Beth Gullen,
M. Gary Newton,
Yung-Chi Cheng,
Reymond F. Schinazi, and
Chung K. Chu
[Full Article - PDF]
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3400-3411
| 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benz[e]indoles: Relationships between Structure and Cytotoxicity for Analogues Bearing Different DNA Minor Groove Binding Subunits
Graham J. Atwell,
Jared J. B. Milbank,
William R. Wilson,
Alison Hogg, and
William A. Denny
[Full Article - PDF]
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3412-3420
| Structure-Activity Relationship of N-(Phenylalkyl)cinnamides as Novel NR2B Subtype-Selective NMDA Receptor Antagonists
Amir P. Tamiz,
Sui Xiong Cai,
Zhang-Lin Zhou,
Po-Wai Yuen,
Robert M. Schelkun,
Edward R. Whittemore,
Eckard Weber,
Richard M. Woodward, and
John F. W. Keana
[Full Article - PDF]
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